Enzyme kinetic and binding studies identify determinants of specificity for the immunomodulatory enzyme ScpA, a C5a inactivating bacterial protease

Enzyme kinetic and binding studies identify determinants of specificity for the immunomodulatory enzyme ScpA, a C5a inactivating bacterial protease

The Streptococcal C5a peptidase (ScpA) specifically inactivates the human complement factor hC5a, a potent anaphylatoxin recently identified as a therapeutic target for treatment of COVID-19 infections. Biologics used to modulate hC5a are predominantly monoclonal antibodies. Here we present data to...

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Bibliographic Details
Main Authors: Malgorzata Teçza, Todd F. Kagawa, Monica Jain, Jakki C. Cooney
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Complement factor C5a
C5a peptidase
COVID-19, cell envelope protease
Immune modulation
Substrate specificity
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037021001367

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http://www.sciencedirect.com/science/article/pii/S2001037021001367

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