TNER: a novel background error suppression method for mutation detection in circulating tumor DNA

TNER: a novel background error suppression method for mutation detection in circulating tumor DNA

Abstract Background Ultra-deep next-generation sequencing of circulating tumor DNA (ctDNA) holds great promise as a tool for the early detection of cancer and for monitoring disease progression and therapeutic responses. However, the low abundance of ctDNA in the bloodstream coupled with technical e...

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Bibliographic Details
Main Authors: Shibing Deng, Maruja Lira, Donghui Huang, Kai Wang, Crystal Valdez, Jennifer Kinong, Paul A. Rejto, Jadwiga Bienkowska, James Hardwick, Tao Xie
Format: Article
Language:English
Published: BMC 2018-10-01
Series:BMC Bioinformatics
Subjects:
ctDNA
Next-generation sequencing
Variant calling
Error suppression
Single-nucleotide variant
Online Access:http://link.springer.com/article/10.1186/s12859-018-2428-3

Internet

http://link.springer.com/article/10.1186/s12859-018-2428-3

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