Identification of Novel Hits of the NSD1 SET Domain by NMR Fragment-Based Screening
Nuclear receptor binding SET domain protein 1 (NSD1), which is a family member of histone methyltransferases, functions to methylate histone H3 on lysine 36 (H3K36). NSD1-related abnormalities are the major cause of Sotos syndrome, and also known to be associated with other human diseases. Inhibitor...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | zho |
| Published: |
Science Press
2019-06-01
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| Series: | Chinese Journal of Magnetic Resonance |
| Subjects: | |
| Online Access: | http://html.rhhz.net/bpxzz/html/20190203.htm |