A Proof of Concept, Phase II Randomized European Trial, on the Efficacy of ALF-5755, a Novel Extracellular Matrix-Targeted Antioxidant in Patients with Acute Liver Diseases.

A Proof of Concept, Phase II Randomized European Trial, on the Efficacy of ALF-5755, a Novel Extracellular Matrix-Targeted Antioxidant in Patients with Acute Liver Diseases.

No efficient medical treatment is available for severe acute hepatitis (SAH) except N-acetylcysteine for acetaminophen-induced acute liver failure. The human C-type lectin Reg3α, referred to as ALF-5755, improved survival in an animal model of acute liver failure and was well tolerated in a phase 1...

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Bibliographic Details
Main Authors: Bertrand Nalpas, Philippe Ichaï, Laure Jamot, Nicolas Carbonell, Marika Rudler, Philippe Mathurin, François Durand, Guido Gerken, Michael Manns, Christian Trautwein, Dominique Larrey, Sylvie Radenne, Christophe Duvoux, Vincent Leroy, Jacques Bernuau, Jamila Faivre, Nicolas Moniaux, Christian Bréchot, Gilles Amouyal, Paul Amouyal, Didier Samuel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4794150?pdf=render

Internet

http://europepmc.org/articles/PMC4794150?pdf=render

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