Differentiation of Inflammation-Responsive Astrocytes from Glial Progenitors Generated from Human Induced Pluripotent Stem Cells

Differentiation of Inflammation-Responsive Astrocytes from Glial Progenitors Generated from Human Induced Pluripotent Stem Cells

Astrocyte dysfunction and neuroinflammation are detrimental features in multiple pathologies of the CNS. Therefore, the development of methods that produce functional human astrocytes represents an advance in the study of neurological diseases. Here we report an efficient method for inflammation-res...

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Bibliographic Details
Main Authors: Renata Santos, Krishna C. Vadodaria, Baptiste N. Jaeger, Arianna Mei, Sabrina Lefcochilos-Fogelquist, Ana P.D. Mendes, Galina Erikson, Maxim Shokhirev, Lynne Randolph-Moore, Callie Fredlender, Sonia Dave, Ruth Oefner, Conor Fitzpatrick, Monique Pena, Jerika J. Barron, Manching Ku, Ahmet M. Denli, Bilal E. Kerman, Patrick Charnay, John R. Kelsoe, Maria C. Marchetto, Fred H. Gage
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:Stem Cell Reports
Subjects:
astrocytes
iPSCs
neuroinflammation
disease modeling
stem cell
co-culture
neuropsychiatric disorders
neurodegenerative disorders
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671117302187

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http://www.sciencedirect.com/science/article/pii/S2213671117302187

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