The behavioural and neuropathologic sexual dimorphism and absence of MIP-3α in tau P301S mouse model of Alzheimer’s disease

The behavioural and neuropathologic sexual dimorphism and absence of MIP-3α in tau P301S mouse model of Alzheimer’s disease

Abstract Background Tau hyper-phosphorylation has been considered a major contributor to neurodegeneration in Alzheimer’s disease (AD) and related tauopathies, and has gained prominence in therapeutic development for AD. To elucidate the pathogenic mechanisms underlying AD and evaluate therapeutic a...

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Bibliographic Details
Main Authors: Yao Sun, Yongqing Guo, Xuejian Feng, Meng Jia, Ning Ai, Yue Dong, Yayuan Zheng, Lu Fu, Bin Yu, Haihong Zhang, Jiaxin Wu, Xianghui Yu, Hui Wu, Wei Kong
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Journal of Neuroinflammation
Subjects:
Alzheimer’s disease
Tauopathies
Sexual dimorphism
Tau P301S transgenic mice
Behavior
Tau hyper-phosphorylation
Online Access:http://link.springer.com/article/10.1186/s12974-020-01749-w

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http://link.springer.com/article/10.1186/s12974-020-01749-w

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