HMM-ModE – Improved classification using profile hidden Markov models by optimising the discrimination threshold and modifying emission probabilities with negative training sequences

HMM-ModE – Improved classification using profile hidden Markov models by optimising the discrimination threshold and modifying emission probabilities with negative training sequences

<p>Abstract</p> <p>Background</p> <p>Profile Hidden Markov Models (HMM) are statistical representations of protein families derived from patterns of sequence conservation in multiple alignments and have been used in identifying remote homologues with considerable succes...

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Bibliographic Details
Main Authors: Nandi Soumyadeep, Desai Dhwani K, Srivastava Prashant K, Lynn Andrew M
Format: Article
Language:English
Published: BMC 2007-03-01
Series:BMC Bioinformatics
Online Access:http://www.biomedcentral.com/1471-2105/8/104

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http://www.biomedcentral.com/1471-2105/8/104

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