Clopidogrel as a donor probe and thioenol derivatives as flexible promoieties for enabling H2S biomedicine

Clopidogrel as a donor probe and thioenol derivatives as flexible promoieties for enabling H2S biomedicine

Hydrogen sulphide (H2S) is a gaseous signalling molecule, which has shown therapeutic value. Here, the authors show that a thioenol metabolite of the antithrombotic drug clopidogrel is an efficient H2S donor and masked thioenols can be linked to existing compounds to develop H2S-releasing agents.

Bibliographic Details
Main Authors: Yaoqiu Zhu, Elkin L. Romero, Xiaodong Ren, Angel J. Sanca, Congkuo Du, Cai Liu, Zubair A. Karim, Fatima Z. Alshbool, Fadi T. Khasawneh, Jiang Zhou, Dafang Zhong, Bin Geng
Format: Article
Language:English
Published: Nature Publishing Group 2018-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06373-0

Internet

https://doi.org/10.1038/s41467-018-06373-0

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