Hiltonol Cocktail Kills Lung Cancer Cells by Activating Cancer-Suppressors, PKR/OAS and Restraining the Tumor Microenvironment

Hiltonol Cocktail Kills Lung Cancer Cells by Activating Cancer-Suppressors, PKR/OAS and Restraining the Tumor Microenvironment

<b> </b>NSCLC (non-small cell lung cancer) is a leading cause of cancer-related deaths worldwide. Clinical trials showed that Hiltonol, a stable dsRNA representing an advanced form of polyI:C (polyinosinic-polycytidilic acid), is an adjuvant cancer-immunomodulator. However, its mechanism...

Full description

Bibliographic Details
Main Authors: Shu-Chun Chang, Bo-Xiang Zhang, Emily Chia-Yu Su, Wei-Ciao Wu, Tsung-Han Hsieh, Andres M. Salazar, Yen-Kuang Lin, Jeak Ling Ding
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
NSCLC (non-small cell lung cancer)
combinatorial treatment with Hiltonol+++ cocktail [Hiltonol+anti-IL6+stattic+AG490]
tumorigenic microenvironment
anti- and pro-tumorigenic cytokine production
tumor-suppressors PKR (protein kinase R) and OAS (2′5′ oligoadenylate synthetase)
Online Access:https://www.mdpi.com/1422-0067/22/4/1626

Internet

https://www.mdpi.com/1422-0067/22/4/1626

Similar Items