Mitochondrial DNA Mutation Analysis in Breast Cancer: Shifting From Germline Heteroplasmy Toward Homoplasmy in Tumors

Mitochondrial DNA Mutation Analysis in Breast Cancer: Shifting From Germline Heteroplasmy Toward Homoplasmy in Tumors

Studies have suggested a potential role of somatic mitochondrial mutations in cancer development. To analyze the landscape of somatic mitochondrial mutation in breast cancer and to determine whether mitochondrial DNA (mtDNA) mutational burden is correlated with overall survival (OS), we sequenced wh...

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Bibliographic Details
Main Authors: Carlos Jhovani Pérez-Amado, Hugo Tovar, Laura Gómez-Romero, Fredy Omar Beltrán-Anaya, Verónica Bautista-Piña, Carlos Dominguez-Reyes, Felipe Villegas-Carlos, Alberto Tenorio-Torres, Luis Alberto Alfaro-Ruíz, Alfredo Hidalgo-Miranda, Silvia Jiménez-Morales
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Oncology
Subjects:
mitochondrial DNA
breast cancer
mutations
heteroplasmy
haplogroups
molecular subtypes
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.572954/full

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https://www.frontiersin.org/articles/10.3389/fonc.2020.572954/full

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