Pathologic tau conformer ensembles induce dynamic, liquid-liquid phase separation events at the nuclear envelope

Pathologic tau conformer ensembles induce dynamic, liquid-liquid phase separation events at the nuclear envelope

Abstract Background The microtubule-associated protein tau forms aggregates in different neurodegenerative diseases called tauopathies. Prior work has shown that a single P301L mutation in tau gene, MAPT, can promote alternative tau folding pathways that correlate with divergent clinical diagnoses....

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Bibliographic Details
Main Authors: Sang-Gyun Kang, Zhuang Zhuang Han, Nathalie Daude, Emily McNamara, Serene Wohlgemuth, Laura Molina-Porcel, Jiri G. Safar, Sue-Ann Mok, David Westaway
Format: Article
Language:English
Published: BMC 2021-09-01
Series:BMC Biology
Subjects:
Tauopathy
Focal tau pathology
Liquid-solid phase transition
Nuclear-cytoplasmic transport
Transgenic mouse
Online Access:https://doi.org/10.1186/s12915-021-01132-y

Internet

https://doi.org/10.1186/s12915-021-01132-y

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