Serp-2, a virus-derived apoptosis and inflammasome inhibitor, attenuates liver ischemia-reperfusion injury in mice

Serp-2, a virus-derived apoptosis and inflammasome inhibitor, attenuates liver ischemia-reperfusion injury in mice

Abstract Background Ischemia-reperfusion injury (IRI) is an antigen-independent, innate immune response to arterial occlusion and ischemia with subsequent paradoxical exacerbation after reperfusion. IRI remains a critical problem after vessel occlusion and infarction or during harvest and surgery in...

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Bibliographic Details
Main Authors: Jordan R. Yaron, Hao Chen, Sriram Ambadapadi, Liqiang Zhang, Amanda M. Tafoya, Barbara H. Munk, Dara N. Wakefield, Jorge Fuentes, Bruno J. Marques, Krishna Harripersaud, Mee Yong Bartee, Jennifer A. Davids, Donghang Zheng, Kenneth Rand, Lisa Dixon, Richard W. Moyer, William L. Clapp, Alexandra R. Lucas
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Journal of Inflammation
Subjects:
Ischemia-reperfusion injury
Liver
Serpin
Immune modulation
Inflammation
Necrosis
Online Access:http://link.springer.com/article/10.1186/s12950-019-0215-1

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http://link.springer.com/article/10.1186/s12950-019-0215-1

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