Rearrangement of the transmembrane domain interfaces associated with the activation of a GPCR hetero-oligomer

Rearrangement of the transmembrane domain interfaces associated with the activation of a GPCR hetero-oligomer

G protein-coupled receptors (GPCRs), such as GABAB, can integrate extracellular signals via allosteric interactions within dimers and oligomers. Here authors use crosslinking and identify two transmembrane interfaces in GABAB which undergo a concerted rearrangement upon agonist activation.

Bibliographic Details
Main Authors: Li Xue, Qian Sun, Han Zhao, Xavier Rovira, Siyu Gai, Qianwen He, Jean-Philippe Pin, Jianfeng Liu, Philippe Rondard
Format: Article
Language:English
Published: Nature Publishing Group 2019-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10834-5

Internet

https://doi.org/10.1038/s41467-019-10834-5

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