Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine

Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine

Bile acid concentrations are controlled by a feedback regulatory pathway whereby activation of the farnesoid X receptor (FXR) represses transcription of both the CYP7A1 gene, encoding the rate-limiting enzyme in the classic bile acid synthesis pathway, and the CYP8B1 gene, required for synthesis of...

Full description

Bibliographic Details
Main Authors: Insook Kim, Sung-Hoon Ahn, Takeshi Inagaki, Mihwa Choi, Shinji Ito, Grace L. Guo, Steven A. Kliewer, Frank J. Gonzalez
Format: Article
Language:English
Published: Elsevier 2007-12-01
Series:Journal of Lipid Research
Subjects:
FXR
FGF15
CYP7A1
CYP8B1
liver-specific FXR null mice
intestine-specific FXR null mice
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520429177

Internet

http://www.sciencedirect.com/science/article/pii/S0022227520429177

Similar Items