New Features on the Expression and Trafficking of mGluR1 Splice Variants Exposed by Two Novel Mutant Mouse Lines

New Features on the Expression and Trafficking of mGluR1 Splice Variants Exposed by Two Novel Mutant Mouse Lines

Metabotropic glutamate receptors (mGluRs) couple to G-proteins to modulate slow synaptic transmission via intracellular second messengers. The first cloned mGluR, mGluR1, regulates motor coordination, synaptic plasticity and synapse elimination. mGluR1 undergoes alternative splicing giving rise to f...

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Bibliographic Details
Main Authors: Rika Naito, Hidetoshi Kassai, Yusuke Sakai, Sabine Schönherr, Masahiro Fukaya, Christoph Schwarzer, Hiroyuki Sakagami, Kazuki Nakao, Atsu Aiba, Francesco Ferraguti
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Molecular Neuroscience
Subjects:
cerebellum
G protein-coupled receptor
CRISPR/Cas9
electron microscopy
glutamate
trafficking
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00439/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2018.00439/full

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