Biglycan- and Sphingosine Kinase-1 Signaling Crosstalk Regulates the Synthesis of Macrophage Chemoattractants

Biglycan- and Sphingosine Kinase-1 Signaling Crosstalk Regulates the Synthesis of Macrophage Chemoattractants

In its soluble form, the extracellular matrix proteoglycan biglycan triggers the synthesis of the macrophage chemoattractants, chemokine (C-C motif) ligand CCL2 and CCL5 through selective utilization of Toll-like receptors (TLRs) and their adaptor molecules. However, the respective downstream signal...

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Bibliographic Details
Main Authors: Louise Tzung-Harn Hsieh, Madalina-Viviana Nastase, Heiko Roedig, Jinyang Zeng-Brouwers, Chiara Poluzzi, Stephanie Schwalm, Christian Fork, Claudia Tredup, Ralf P. Brandes, Malgorzata Wygrecka, Andrea Huwiler, Josef Pfeilschifter, Liliana Schaefer
Format: Article
Language:English
Published: MDPI AG 2017-03-01
Series:International Journal of Molecular Sciences
Subjects:
damage-associated molecular pattern
small leucine-rich proteoglycan
toll-like receptors
chemoattractant
extracellular matrix
lipid signaling
sphingolipid
macrophage
Online Access:http://www.mdpi.com/1422-0067/18/3/595

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http://www.mdpi.com/1422-0067/18/3/595

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