Osteopontin That Is Elevated in the Airways during COPD Impairs the Antibacterial Activity of Common Innate Antibiotics.

Bacterial infections of the respiratory tract contribute to exacerbations and disease progression in chronic obstructive pulmonary disease (COPD). There is also an increased risk of invasive pneumococcal disease in COPD. The underlying mechanisms are not fully understood but include impaired mucocil...

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Bibliographic Details
Main Authors: Anele Gela, Ravi K V Bhongir, Michiko Mori, Paul Keenan, Matthias Mörgelin, Jonas S Erjefält, Heiko Herwald, Arne Egesten, Gopinath Kasetty
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4712133?pdf=render