Intramolecular Domain Movements of Free and Bound pMHC and TCR Proteins: A Molecular Dynamics Simulation Study

Intramolecular Domain Movements of Free and Bound pMHC and TCR Proteins: A Molecular Dynamics Simulation Study

The interaction of antigenic peptides (p) and major histocompatibility complexes (pMHC) with T-cell receptors (TCR) is one of the most important steps during the immune response. Here we present a molecular dynamics simulation study of bound and unbound TCR and pMHC proteins of the LC13-HLA-B*44:05-...

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Bibliographic Details
Main Authors: Rudolf Karch, Claudia Stocsits, Nevena Ilieva, Wolfgang Schreiner
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Cells
Subjects:
molecular dynamics simulation
major histocompatibility complex
antigen
T-cell receptor
domain movements
Online Access:https://www.mdpi.com/2073-4409/8/7/720

Internet

https://www.mdpi.com/2073-4409/8/7/720

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