SCF/C-Kit/JNK/AP-1 Signaling Pathway Promotes Claudin-3 Expression in Colonic Epithelium and Colorectal Carcinoma

SCF/C-Kit/JNK/AP-1 Signaling Pathway Promotes Claudin-3 Expression in Colonic Epithelium and Colorectal Carcinoma

Claudin-3 is a major protein of tight junctions (TJs) in the intestinal epithelium and is critical for maintaining cell-cell adhesion, barrier function, and epithelium polarity. Recent studies have shown high claudin-3 levels in several solid tumors, but the regulation mechanism of claudin-3 express...

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Bibliographic Details
Main Authors: Yaxi Wang, Tingyi Sun, Haimei Sun, Shu Yang, Dandan Li, Deshan Zhou
Format: Article
Language:English
Published: MDPI AG 2017-04-01
Series:International Journal of Molecular Sciences
Subjects:
claudins
colorectal cancer
c-kit
claudin-3
c-Jun N-terminal kinase
activator protein-1
Online Access:http://www.mdpi.com/1422-0067/18/4/765

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http://www.mdpi.com/1422-0067/18/4/765

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