Orexin Receptor Multimerization versus Functional Interactions: Neuropharmacological Implications for Opioid and Cannabinoid Signalling and Pharmacogenetics

Orexin Receptor Multimerization versus Functional Interactions: Neuropharmacological Implications for Opioid and Cannabinoid Signalling and Pharmacogenetics

Orexins/hypocretins are neuropeptides formed by proteolytic cleavage of a precursor peptide, which are produced by neurons found in the lateral hypothalamus. The G protein-coupled receptors (GPCRs) for these ligands, the OX1 and OX2 orexin receptors, are more widely expressed throughout the central...

Full description

Bibliographic Details
Main Authors: Miles D. Thompson, Takeshi Sakurai, Innocenzo Rainero, Mary C. Maj, Jyrki P. Kukkonen
Format: Article
Language:English
Published: MDPI AG 2017-10-01
Series:Pharmaceuticals
Subjects:
orexin/hypocretin
OX1 orexin receptor
OX2 orexin receptor
homo-dimerization
hetero-dimerization
opioid receptor
CB1 cannabinoid receptor
status epilepticus
feeding behavior
sleep disorder
Online Access:https://www.mdpi.com/1424-8247/10/4/79

Internet

https://www.mdpi.com/1424-8247/10/4/79

Similar Items