Exogenous Hydrogen Sulfide Ameliorates Diabetic Myocardial Fibrosis by Inhibiting Cell Aging Through SIRT6/AMPK Autophagy

Exogenous Hydrogen Sulfide Ameliorates Diabetic Myocardial Fibrosis by Inhibiting Cell Aging Through SIRT6/AMPK Autophagy

Stress aging of myocardial cells participates in the mechanism of myocardial fibrosis (MF). Previous studies have shown that hydrogen sulfide (H2S) can improve MF, however the specific internal mechanism remains still unclear. Therefore, this study aims to explore whether H2S can improve myocardial...

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Bibliographic Details
Main Authors: Yaling Li, Maojun Liu, Xiong Song, Xia Zheng, Jiali Yi, Da Liu, Sen Wang, Chun Chu, Jun Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Pharmacology
Subjects:
hydrogen sulfide
myocardial fibrosis
cell aging
Sirt6/AMPK pathway
autophagy
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.01150/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.01150/full

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