βTrCP is Required for HIV-1 Vpu Modulation of CD4, GaLV Env, and BST-2/Tetherin

βTrCP is Required for HIV-1 Vpu Modulation of CD4, GaLV Env, and BST-2/Tetherin

The Human immunodeficiency virus-1 (HIV-1) accessory protein Vpu modulates numerous proteins, including the host proteins CD4 and BST-2/tetherin. Vpu interacts with the Skp, Cullin, F-Box (SCF) ubiquitin ligase through interactions with the F-Box protein βTrCP (1 and/or 2). This interaction...

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Bibliographic Details
Main Authors: Yul Eum Song, Daniel Cyburt, Tiffany M. Lucas, Devon A. Gregory, Terri D. Lyddon, Marc C. Johnson
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Viruses
Subjects:
HIV-1
Vpu
CD4
GaLV Env
BST-2/tetherin
Cullin1
βTrCP
Online Access:http://www.mdpi.com/1999-4915/10/10/573

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http://www.mdpi.com/1999-4915/10/10/573

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