Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis

Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis

Brain metastases are a major reason for lung cancer mortality. Here, the authors modify lonidamine to target mitochondria, and show its therapeutic efficacy in inhibiting lung cancer brain metastasis by inducing autophagic cell death in cancer cells.

Bibliographic Details
Main Authors: Gang Cheng, Qi Zhang, Jing Pan, Yongik Lee, Olivier Ouari, Micael Hardy, Monika Zielonka, Charles R. Myers, Jacek Zielonka, Katherine Weh, Andrew C. Chang, Guoan Chen, Laura Kresty, Balaraman Kalyanaraman, Ming You
Format: Article
Language:English
Published: Nature Publishing Group 2019-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10042-1

Internet

https://doi.org/10.1038/s41467-019-10042-1

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