Altered Ca<sup>2+</sup> Handling and Oxidative Stress Underlie Mitochondrial Damage and Skeletal Muscle Dysfunction in Aging and Disease

Altered Ca<sup>2+</sup> Handling and Oxidative Stress Underlie Mitochondrial Damage and Skeletal Muscle Dysfunction in Aging and Disease

Skeletal muscle contraction relies on both high-fidelity calcium (Ca<sup>2+</sup>) signals and robust capacity for adenosine triphosphate (ATP) generation. Ca<sup>2+</sup> release units (CRUs) are highly organized junctions between the terminal cisternae of the sarcoplasmic r...

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Bibliographic Details
Main Authors: Antonio Michelucci, Chen Liang, Feliciano Protasi, Robert T. Dirksen
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Metabolites
Subjects:
Ca<sup>2+</sup> signaling
mitochondria
oxidative stress
skeletal muscle disease
atrophy
sarcopenia
Online Access:https://www.mdpi.com/2218-1989/11/7/424

Internet

https://www.mdpi.com/2218-1989/11/7/424

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