Glycan-Induced Protein Dynamics in Human Norovirus P Dimers Depend on Virus Strain and Deamidation Status

Glycan-Induced Protein Dynamics in Human Norovirus P Dimers Depend on Virus Strain and Deamidation Status

Noroviruses are the major cause of viral gastroenteritis and re-emerge worldwide every year, with GII.4 currently being the most frequent human genotype. The norovirus capsid protein VP1 is essential for host immune response. The P domain mediates cell attachment via histo blood-group antigens (HBGA...

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Bibliographic Details
Main Authors: Jasmin Dülfer, Hao Yan, Maxim N. Brodmerkel, Robert Creutznacher, Alvaro Mallagaray, Thomas Peters, Carl Caleman, Erik G. Marklund, Charlotte Uetrecht
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Molecules
Subjects:
glycan interaction
norovirus capsid protein VP1
protruding domain
HDX-MS
native MS
hydrogen/deuterium exchange mass spectrometry
Online Access:https://www.mdpi.com/1420-3049/26/8/2125

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https://www.mdpi.com/1420-3049/26/8/2125

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