Insight into resistance mechanism of anaplastic lymphoma kinase to alectinib and JH-VIII-157-02 caused by G1202R solvent front mutation

Insight into resistance mechanism of anaplastic lymphoma kinase to alectinib and JH-VIII-157-02 caused by G1202R solvent front mutation

Han Wang,1–3 Yao Wang,1–3 Wentao Guo,4 Bin Du,1–3 Xiaobing Huang,1–3 Riping Wu,1–3 Baoyu Yang,1–3 Xiaoyan Lin,1–3,5 Yilan Wu6 1Department of Medical Oncology, Fujian Medical University Union Hospital, Fuzhou, People’s R...

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Bibliographic Details
Main Authors: Wang H, Wang Y, Guo W, Du B, Huang X, Wu R, Yang B, Lin X, Wu Y
Format: Article
Language:English
Published: Dove Medical Press 2018-05-01
Series:Drug Design, Development and Therapy
Subjects:
ALK
G1202R
Alectinib
JH-VIII-157-02
Theoretical study
Resistance mechanisms
Online Access:https://www.dovepress.com/insight-into-resistance-mechanism-of-anaplastic-lymphoma-kinase-to-ale-peer-reviewed-article-DDDT

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https://www.dovepress.com/insight-into-resistance-mechanism-of-anaplastic-lymphoma-kinase-to-ale-peer-reviewed-article-DDDT

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