HIV protein sequence hotspots for crosstalk with host hub proteins.

HIV proteins target host hub proteins for transient binding interactions. The presence of viral proteins in the infected cell results in out-competition of host proteins in their interaction with hub proteins, drastically affecting cell physiology. Functional genomics and interactome datasets can be...

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Bibliographic Details
Main Authors: Mahdi Sarmady, William Dampier, Aydin Tozeren
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3156123?pdf=render