Light Sheet Microscopy-Assisted 3D Analysis of SARS-CoV-2 Infection in the Respiratory Tract of the Ferret Model

Light Sheet Microscopy-Assisted 3D Analysis of SARS-CoV-2 Infection in the Respiratory Tract of the Ferret Model

The visualization of viral pathogens in infected tissues is an invaluable tool to understand spatial virus distribution, localization, and cell tropism in vivo. Commonly, virus-infected tissues are analyzed using conventional immunohistochemistry in paraffin-embedded thin sections. Here, we demonstr...

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Bibliographic Details
Main Authors: Luca M. Zaeck, David Scheibner, Julia Sehl, Martin Müller, Donata Hoffmann, Martin Beer, Elsayed M. Abdelwhab, Thomas C. Mettenleiter, Angele Breithaupt, Stefan Finke
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Viruses
Subjects:
SARS-CoV-2
COVID-19
3D immunofluorescence
light sheet microscopy
confocal laser scanning microscopy
tissue optical clearing
Online Access:https://www.mdpi.com/1999-4915/13/3/529

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https://www.mdpi.com/1999-4915/13/3/529

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