The Responses of Mouse Preimplantation Embryos to Leptin In Vitro in a Transgenerational Model for Obesity

The Responses of Mouse Preimplantation Embryos to Leptin In Vitro in a Transgenerational Model for Obesity

The aim of the present study was to test the hypothesis that leptin can directly mediate the negative effect of maternal obesity on preimplantation embryos. As previously shown, maternal obesity retards early embryonic development in vivo and increases the incidence of apoptosis in blastocysts. When...

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Bibliographic Details
Main Authors: Martina Kšiňanová, Štefan Čikoš, Janka Babel’ová, Zuzana Šefčíková, Alexandra Špirková, Juraj Koppel, Dušan Fabian
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Endocrinology
Subjects:
leptin
maternal obesity
mouse model
preimplantation embryo
in vitro culture
apoptosis
Online Access:http://journal.frontiersin.org/article/10.3389/fendo.2017.00233/full

Internet

http://journal.frontiersin.org/article/10.3389/fendo.2017.00233/full

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