P-glycoprotein-mediated resistance to chemotherapy in cancer cells: using recombinant cytosolic domains to establish structure-function relationships

P-glycoprotein-mediated resistance to chemotherapy in cancer cells: using recombinant cytosolic domains to establish structure-function relationships

Resistance to chemotherapy in cancer cells is mainly mediated by overexpression of P-glycoprotein (Pgp), a plasma membrane ATP-binding cassette (ABC) transporter which extrudes cytotoxic drugs at the expense of ATP hydrolysis. Pgp consists of two homologous halves each containing a transmembrane dom...

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Bibliographic Details
Main Authors: Di Pietro A., Dayan G., Conseil G., Steinfels E., Krell T., Trompier D., Baubichon-Cortay H., Jault J.-M.
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 1999-01-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
P-glycoprotein (Pgp)
multidrug resistance
anticancer chemotherapy
ATP
steroids
flavonoids
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000800001

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000800001

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