Transient ischemia facilitates neuronal chloride accumulation and severity of seizures
Abstract Objective Preceding oxygen glucose deprivation (OGD) and ongoing seizures have both been reported to increase neuronal chloride concentration ([Cl−]i), which may contribute to anticonvulsant failure by reversing the direction of chloride currents at inhibitory GABAA synapses. Methods The ef...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-09-01
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| Series: | Annals of Clinical and Translational Neurology |
| Online Access: | https://doi.org/10.1002/acn3.617 |