Glycolipids Recognized by A2B5 Antibody Promote Proliferation, Migration, and Clonogenicity in Glioblastoma Cells

Glycolipids Recognized by A2B5 Antibody Promote Proliferation, Migration, and Clonogenicity in Glioblastoma Cells

A2B5+ cells isolated from human glioblastomas exhibit cancer stem cell properties. The A2B5 epitope belongs to the sialoganglioside family and is synthetized by the ST8 alpha-N-acetyl-neuraminidase α-2,8-sialyltransferase 3 (ST8SIA3) enzyme. Glycolipids represent attractive targets for soli...

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Bibliographic Details
Main Authors: Nathalie Baeza-Kallee, Raphaël Bergès, Aurélie Soubéran, Carole Colin, Emilie Denicolaï, Romain Appay, Aurélie Tchoghandjian, Dominique Figarella-Branger
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Cancers
Subjects:
A2B5
ST8SIA3
glioblastoma
cancer stem cell
tumorigenicity
Online Access:https://www.mdpi.com/2072-6694/11/9/1267

Internet

https://www.mdpi.com/2072-6694/11/9/1267

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