Female AhR Knockout Mice Develop a Minor Renal Insufficiency in an Adenine-Diet Model of Chronic Kidney Disease

Female AhR Knockout Mice Develop a Minor Renal Insufficiency in an Adenine-Diet Model of Chronic Kidney Disease

Cardiovascular complications observed in chronic kidney disease (CKD) are associated with aryl hydrocarbon receptor (AhR) activation by tryptophan-derived uremic toxins—mainly indoxyl sulfate (IS). AhR is a ligand-activated transcription factor originally characterized as a receptor of xenobiotics i...

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Bibliographic Details
Main Authors: Camélia Makhloufi, Fanny Nicolas, Nathalie McKay, Samantha Fernandez, Guillaume Hache, Philippe Garrigue, Philippe Brunet, Benjamin Guillet, Stéphane Burtey, Stéphane Poitevin
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
chronic kidney disease
adenine
mouse model
aryl hydrocarbon receptor, indoxyl sulfate
Online Access:https://www.mdpi.com/1422-0067/21/7/2483

Internet

https://www.mdpi.com/1422-0067/21/7/2483

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