A Relatively Small Gradient of Extracellular pH Directs Migration of MDA-MB-231 Cells In Vitro

A Relatively Small Gradient of Extracellular pH Directs Migration of MDA-MB-231 Cells In Vitro

Hematogenous tumor metastasis begins with the invasion and spread of primary tumor cells in the local tissue leading to intravasation. We hypothesized that tumor cells might actively migrate toward intratumor vessels with the extracellular metabolic gradient acting as a guiding cue. Here, we determi...

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Bibliographic Details
Main Authors: Eiji Takahashi, Daisuke Yamaguchi, Yoshihisa Yamaoka
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
metastasis
cell migration
pH gradient
oxygen gradient
MDA-MB-231 cells
Online Access:https://www.mdpi.com/1422-0067/21/7/2565

Internet

https://www.mdpi.com/1422-0067/21/7/2565

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