CDKN2A Copy Number Loss Is an Independent Prognostic Factor in HPV-Negative Head and Neck Squamous Cell Carcinoma

CDKN2A Copy Number Loss Is an Independent Prognostic Factor in HPV-Negative Head and Neck Squamous Cell Carcinoma

BackgroundHPV infection is associated with high p16 expression and good prognosis in head and neck squamous cell carcinomas (HNSCCs). Analysis of CDKN2A, the gene encoding p16, may further elucidate the association between p16 expression and prognosis. We sought to determine whether CDKN2A copy numb...

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Bibliographic Details
Main Authors: William S. Chen, Ranjit S. Bindra, Allen Mo, Thomas Hayman, Zain Husain, Joseph N. Contessa, Stephen G. Gaffney, Jeffrey P. Townsend, James B. Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Oncology
Subjects:
CDKN2A
head and neck neoplasms
prognostic biomarkers
genomics and genetics
outcomes assessment
Online Access:http://journal.frontiersin.org/article/10.3389/fonc.2018.00095/full

Internet

http://journal.frontiersin.org/article/10.3389/fonc.2018.00095/full

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