Intranasal delivery of mesenchymal stem cell‐derived extracellular vesicles exerts immunomodulatory and neuroprotective effects in a 3xTg model of Alzheimer's disease

Intranasal delivery of mesenchymal stem cell‐derived extracellular vesicles exerts immunomodulatory and neuroprotective effects in a 3xTg model of Alzheimer's disease

Abstract The critical role of neuroinflammation in favoring and accelerating the pathogenic process in Alzheimer's disease (AD) increased the need to target the cerebral innate immune cells as a potential therapeutic strategy to slow down the disease progression. In this scenario, mesenchymal s...

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Bibliographic Details
Main Authors: Morris Losurdo, Matteo Pedrazzoli, Claudia D'Agostino, Chiara A. Elia, Francesca Massenzio, Elena Lonati, Mario Mauri, Laura Rizzi, Laura Molteni, Elena Bresciani, Erica Dander, Giovanna D'Amico, Alessandra Bulbarelli, Antonio Torsello, Michela Matteoli, Mario Buffelli, Silvia Coco
Format: Article
Language:English
Published: Wiley 2020-09-01
Series:Stem Cells Translational Medicine
Subjects:
Alzheimer's disease
dendritic spines
extracellular vesicles
inflammation
mesenchymal stem cells
microglia
Online Access:https://doi.org/10.1002/sctm.19-0327

Internet

https://doi.org/10.1002/sctm.19-0327

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