Transiently proliferating perivascular microglia harbor M1 type and precede cerebrovascular changes in a chronic hypertension model

Transiently proliferating perivascular microglia harbor M1 type and precede cerebrovascular changes in a chronic hypertension model

Abstract Background Microglia play crucial roles in the maintenance of brain homeostasis. Activated microglia show a biphasic influence, promoting beneficial repair and causing harmful damage via M2 and M1 microglia, respectively. It is well-known that microglia are initially activated to the M2 sta...

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Bibliographic Details
Main Authors: Takashi Koizumi, Katsutoshi Taguchi, Ikuko Mizuta, Hiroe Toba, Makoto Ohigashi, Okihiro Onishi, Kazuya Ikoma, Seiji Miyata, Tetsuo Nakata, Masaki Tanaka, Sébastien Foulquier, Harry W. M. Steinbusch, Toshiki Mizuno
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Journal of Neuroinflammation
Subjects:
Neuroinflammation
Cerebral small vessel disease
Chronic hypertension
Perivascular microglia
Proliferation
Online Access:http://link.springer.com/article/10.1186/s12974-019-1467-7

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http://link.springer.com/article/10.1186/s12974-019-1467-7

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