Novel 3′-Substituted-1′,2′,4′-Oxadiazole Derivatives of 18βH-Glycyrrhetinic Acid and Their O-Acylated Amidoximes: Synthesis and Evaluation of Antitumor and Anti-Inflammatory Potential In Vitro and In Vivo

Novel 3′-Substituted-1′,2′,4′-Oxadiazole Derivatives of 18βH-Glycyrrhetinic Acid and Their O-Acylated Amidoximes: Synthesis and Evaluation of Antitumor and Anti-Inflammatory Potential In Vitro and In Vivo

A series of novel 18βH-glycyrrhetinic acid (GA) derivatives containing 3′-(alkyl/phenyl/pyridin(-2″, -3″, and -4″)-yl)-1′,2′,4′-oxadiazole moieties at the C-30 position were synthesized by condensation of triterpenoid’s carboxyl group with corresponding amidoximes and further cyclization. Screening...

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Bibliographic Details
Main Authors: Andrey V. Markov, Aleksandra V. Sen’kova, Irina I. Popadyuk, Oksana V. Salomatina, Evgeniya B. Logashenko, Nina I. Komarova, Anna A. Ilyina, Nariman F. Salakhutdinov, Marina A. Zenkova
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:International Journal of Molecular Sciences
Subjects:
18βH-glycyrrhetinic acid
derivatives
oxadiazole
heterocyclic moiety
antitumor activity
anti-inflammatory activity
Online Access:https://www.mdpi.com/1422-0067/21/10/3511

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https://www.mdpi.com/1422-0067/21/10/3511

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