TNF Drives Monocyte Dysfunction with Age and Results in Impaired Anti-pneumococcal Immunity.

TNF Drives Monocyte Dysfunction with Age and Results in Impaired Anti-pneumococcal Immunity.

Monocyte phenotype and output changes with age, but why this occurs and how it impacts anti-bacterial immunity are not clear. We found that, in both humans and mice, circulating monocyte phenotype and function was altered with age due to increasing levels of TNF in the circulation that occur as part...

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Bibliographic Details
Main Authors: Alicja Puchta, Avee Naidoo, Chris P Verschoor, Dessi Loukov, Netusha Thevaranjan, Talveer S Mandur, Phuong-Son Nguyen, Manel Jordana, Mark Loeb, Zhou Xing, Lester Kobzik, Maggie J Larché, Dawn M E Bowdish
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1005368

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https://doi.org/10.1371/journal.ppat.1005368

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