Calmodulin fishing with a structurally disordered bait triggers CyaA catalysis.

Calmodulin fishing with a structurally disordered bait triggers CyaA catalysis.

Once translocated into the cytosol of target cells, the catalytic domain (AC) of the adenylate cyclase toxin (CyaA), a major virulence factor of Bordetella pertussis, is potently activated by binding calmodulin (CaM) to produce supraphysiological levels of cAMP, inducing cell death. Using a combinat...

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Bibliographic Details
Main Authors: Darragh P O'Brien, Dominique Durand, Alexis Voegele, Véronique Hourdel, Marilyne Davi, Julia Chamot-Rooke, Patrice Vachette, Sébastien Brier, Daniel Ladant, Alexandre Chenal
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-12-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.2004486

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https://doi.org/10.1371/journal.pbio.2004486

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