Dynamic micelles with detachable PEGylation at tumoral extracellular pH for enhanced chemotherapy

Dynamic micelles with detachable PEGylation at tumoral extracellular pH for enhanced chemotherapy

Although surface PEGylation of nanomedicines can decrease serum protein adsorption in vivo, it also blocks uptake by tumor cells. This dilemma could be overcome by employing detachably PEGylated strategy at tumoral extracellular microenvironment to achieve improved cellular uptake while prolonged ci...

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Bibliographic Details
Main Authors: Guoqing Yan, Panpan Zhang, Jun Wang, Xin Wang, Rupei Tang
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:Asian Journal of Pharmaceutical Sciences
Subjects:
Micelles
Ortho ester
PEGylation
Size transition
Antitumor
Online Access:http://www.sciencedirect.com/science/article/pii/S1818087619309535

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http://www.sciencedirect.com/science/article/pii/S1818087619309535

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