Antagonizing Retinoic Acid-Related-Orphan Receptor Gamma Activity Blocks the T Helper 17/Interleukin-17 Pathway Leading to Attenuated Pro-inflammatory Human Keratinocyte and Skin Responses

Antagonizing Retinoic Acid-Related-Orphan Receptor Gamma Activity Blocks the T Helper 17/Interleukin-17 Pathway Leading to Attenuated Pro-inflammatory Human Keratinocyte and Skin Responses

The nuclear hormone receptor retinoic acid receptor-related-orphan-receptor-gamma t (RORγt) is the key transcription factor required for Th17 cell differentiation and for production of IL-17 family cytokines by innate and adaptive immune cells. Dysregulated Th17 immune responses have been associated...

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Bibliographic Details
Main Authors: Florence Ecoeur, Jessica Weiss, Klemens Kaupmann, Samuel Hintermann, David Orain, Christine Guntermann
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
retinoic acid receptor-related-orphan-receptor-gamma t
nuclear hormone receptor
T helper 17 differentiation
IL-17
autoimmunity
keratinocytes
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00577/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00577/full

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