Amino Acid Substitutions in NS5 Contribute Differentially to Tembusu Virus Attenuation in Ducklings and Cell Cultures

Amino Acid Substitutions in NS5 Contribute Differentially to Tembusu Virus Attenuation in Ducklings and Cell Cultures

Tembusu virus (TMUV), a highly infectious pathogenic flavivirus, causes severe egg-drop and encephalitis in domestic waterfowl, while the determinants responsible for viral pathogenicity are largely unknown. In our previous studies, virulent strain JXSP<sub>2-4</sub> had been completely...

Full description

Bibliographic Details
Main Authors: Xue Sun, Mengxu Sun, Lijiao Zhang, Ziding Yu, Jinxin Li, Wanying Xie, Jingliang Su
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Viruses
Subjects:
Tembusu virus
attenuation
RNA-dependent RNA polymerase
chimeric viruses
viral replication
Online Access:https://www.mdpi.com/1999-4915/13/5/921

Internet

https://www.mdpi.com/1999-4915/13/5/921

Similar Items