Astrocytes Modify Migration of PBMCs Induced by β-Amyloid in a Blood-Brain Barrier in vitro Model

Astrocytes Modify Migration of PBMCs Induced by β-Amyloid in a Blood-Brain Barrier in vitro Model

BackgroundThe brain is protected by the blood-brain barrier (BBB), constituted by endothelial cells supported by pericytes and astrocytes. In Alzheimer’s disease a dysregulation of the BBB occurs since the early phases of the disease leading to an increased access of solutes and immune cells that ca...

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Bibliographic Details
Main Authors: Simona Federica Spampinato, Sara Merlo, Evelina Fagone, Mary Fruciano, Cristina Barbagallo, Takashi Kanda, Yasuteru Sano, Michele Purrello, Carlo Vancheri, Marco Ragusa, Maria Angela Sortino
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Alzheimer’s disease
endothelial cells
cytokines
leukocytes
ICAM-1
VE-cadherin
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00337/full

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https://www.frontiersin.org/article/10.3389/fncel.2019.00337/full

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