Small Angle X-ray Scattering, Molecular Modeling, and Chemometric Studies from a Thrombin-Like (Lmr-47) Enzyme of <i>Lachesis m. rhombeata</i> Venom

Small Angle X-ray Scattering, Molecular Modeling, and Chemometric Studies from a Thrombin-Like (Lmr-47) Enzyme of <i>Lachesis m. rhombeata</i> Venom

Introduction: Snakebite envenomation is considered a neglected tropical disease, and SVTLEs critical elements are involved in serious coagulopathies that occur on envenoming. Although some enzymes of this group have been structurally investigated, it is essential to characterize other proteins to be...

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Bibliographic Details
Main Authors: Salvatore Giovanni De-Simone, Guilherme Curty Lechuga, Paloma Napoleão-Pêgo, Larissa Rodrigues Gomes, David William Provance, Vinícius Dias Nirello, Ana Carolina Rennó Sodero, Herbert Leonel de Mattos Guedes
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Molecules
Subjects:
<i>Lachelis m. rhombeata</i>
serine protease
SVTLE
solution structure
protein shape
guanidine inhibitors
Online Access:https://www.mdpi.com/1420-3049/26/13/3930

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https://www.mdpi.com/1420-3049/26/13/3930

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