Cholesterol retention in Alzheimer's brain is responsible for high β- and γ-secretase activities and Aβ production

Cholesterol retention in Alzheimer's brain is responsible for high β- and γ-secretase activities and Aβ production

Alzheimer's disease (AD) is characterized by overproduction of Aβ derived from APP cleavage via β- and γ-secretase pathway. Recent evidence has linked altered cholesterol metabolism to AD pathogenesis. In this study, we show that AD brain had significant cholesterol retention and high β- and γ-...

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Bibliographic Details
Main Authors: Huaqi Xiong, Debbie Callaghan, Aimee Jones, Douglas G. Walker, Lih-Fen Lue, Thomas G. Beach, Lucia I. Sue, John Woulfe, Huaxi Xu, Danica B. Stanimirovic, Wandong Zhang
Format: Article
Language:English
Published: Elsevier 2008-03-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Cholesterol retention
Nuclear receptors
β- and γ-secretases
Aβ production
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996107002380

Internet

http://www.sciencedirect.com/science/article/pii/S0969996107002380

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