Retinoblastoma from human stem cell-derived retinal organoids

Retinoblastoma from human stem cell-derived retinal organoids

Retinoblastoma is a heritable pediatric cancer driven by mutations in RB1. Here, the authors demonstrate the first patient derived model of retinoblastoma using iPSCs from patients with germline mutations in RB1.

Bibliographic Details
Main Authors: Jackie L. Norrie, Anjana Nityanandam, Karen Lai, Xiang Chen, Matthew Wilson, Elizabeth Stewart, Lyra Griffiths, Hongjian Jin, Gang Wu, Brent Orr, Quynh Tran, Sariah Allen, Colleen Reilly, Xin Zhou, Jiakun Zhang, Kyle Newman, Dianna Johnson, Rachel Brennan, Michael A. Dyer
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-24781-7

Internet

https://doi.org/10.1038/s41467-021-24781-7

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