Anti-Apoptotic Effects of Recombinant Human Hepatocyte Growth Factor on Hepatocytes Were Associated with Intrahepatic Hemorrhage Suppression Indicated by the Preservation of Prothrombin Time

Anti-Apoptotic Effects of Recombinant Human Hepatocyte Growth Factor on Hepatocytes Were Associated with Intrahepatic Hemorrhage Suppression Indicated by the Preservation of Prothrombin Time

Hepatocyte growth factor (HGF) is an endogenously expressed bioactive substance that has a strong anti-apoptotic effect. In this study, we biochemically and histologically characterized the effects of rh-HGF on in vitro human hepatocyte injury and mouse acute liver failure (ALF) models, both of whic...

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Bibliographic Details
Main Authors: Sotaro Motoi, Hiroko Toyoda, Takashi Obara, Etsuko Ohta, Yoshihisa Arita, Kana Negishi, Katsuhiro Moriya, Yoshikazu Kuboi, Motohiro Soejima, Toshio Imai, Akio Ido, Hirohito Tsubouchi, Tetsu Kawano
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:International Journal of Molecular Sciences
Subjects:
acute liver failure
cytokeratin-18
Fas antigen
hepatocyte growth factor
prothrombin time
Online Access:https://www.mdpi.com/1422-0067/20/8/1821

Internet

https://www.mdpi.com/1422-0067/20/8/1821

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