ERK signaling is required for VEGF-A/VEGFR2-induced differentiation of porcine adipose-derived mesenchymal stem cells into endothelial cells

ERK signaling is required for VEGF-A/VEGFR2-induced differentiation of porcine adipose-derived mesenchymal stem cells into endothelial cells

Abstract Background Cell-based therapy that can rejuvenate the endothelium with stimulated adipose-derived mesenchymal stem cells (AMSCs) is a promising therapeutic strategy for the re-endothelialization of denuded arteries at the stenting site. Previously, we have shown that silencing of MMP-2 and...

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Bibliographic Details
Main Authors: Sami G. Almalki, Devendra K. Agrawal
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Stem Cell Research & Therapy
Subjects:
Adipose-derived mesenchymal stem cells
Endothelial cell differentiation
Vascular endothelial growth factor receptor type 2
Mitogen-activated protein kinase
Extracellular signal-regulated kinase 1/2
c-Jun NH2-terminal kinase
Online Access:http://link.springer.com/article/10.1186/s13287-017-0568-4

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http://link.springer.com/article/10.1186/s13287-017-0568-4

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