Generation of human induced pluripotent stem cell line carrying SCN5AC2204>T Brugada mutation (MUSli009-A-1) introduced by CRISPR/Cas9-mediated genome editing

Generation of human induced pluripotent stem cell line carrying SCN5AC2204>T Brugada mutation (MUSli009-A-1) introduced by CRISPR/Cas9-mediated genome editing

Human induced pluripotent stem cells (hiPSCs) derived from dermal fibroblasts having wild type (WT) SCN5A were engineered by CRISPR/Cas9-mediated genome editing to harbor a specific point mutation (C2204>T) in SCN5A, which results in a substitution of the WT alanine by valine at codon 735 (A735V)...

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Bibliographic Details
Main Authors: Paweorn Angsutararux, Sudjit Luanpitpong, Pimjai Chingsuwanrote, Kantpitchar Supraditaporn, Supaporn Waeteekul, Papussorn Terbto, Chanchao Lorthongpanich, Chuti Laowtammathron, Yaowalak U-Pratya, Surapol Issaragrisil
Format: Article
Language:English
Published: Elsevier 2019-12-01
Series:Stem Cell Research
Online Access:http://www.sciencedirect.com/science/article/pii/S187350611930248X

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http://www.sciencedirect.com/science/article/pii/S187350611930248X

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